Specification
Entrez GeneID | 3569 |
Aliases | HGF; HSF; BSF2; IL-6; IFNB2 |
Clone# | 6D9A1 |
Host/Isotype | Mouse IgG1 |
Storage | 4℃; -20℃ for long term storage. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human IL-6 expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application
ELISA | 1/10000 |
Description
Interleukine 6 (IL-6) is a cytokine produced primarily by stimulated monocytes, fibroblasts and epithelial cells. It has a wide variety of biological functions through activating a cellsurface signaling assembly composed of IL6, IL6RA, and the shared signaling receptor gp130. The cytokine plays an essential role in the final differentiation of b-cells into Igsecreting cells, and induces myeloma, plasmacytoma growth, nerve cells differentiations. In addition, IL-6 is an important regulator of acute phase reaction.
References
1. Ota, N. et al. 2001. J. Hum. Genet. 46: 267-272.
Diagram