APP
图片
- Immunohistochemistry
Immunohistochemical analysis of paraffin-embedded human Alzheimer brain tissue, showing cytoplasmic localization using APP mouse mAb with DAB staining.
Mouse Antibody to APP
Catalog#
: 20069
| Size/Concentration： | 50ul | 100μl | |
| Price:￥ | 1280 | 2180 |
Instruction: 
Specification
| Entrez GeneID | 351 |
| Aliases | APP |
| Clone# | 1B11F3 |
| Host/Isotype | Mouse IgG2a |
| Storage | 4℃; -20℃ for long term storage. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of APP expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application
| ELISA | 1/10000 |
| IHC | 1/200 - 1/1000 |
Description
Amyloid precursor protein(APP) ,with 32-amino acid protein (about 35 kDa), is part of a super-family of transmembrane and secreted proteins. It appears to have a number of roles, including regulation of haemostasis and mediation of neuroprotection. APP undergoes alternative splicing, resulting in several isoforms . Proteolytic cleavage of amyloid precursor protein leads to the formation of the 4 kDa amyloid beta/A4 protein, which is present in human platelets. APP is also involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer patients.
References
1. Yuzhi Chen, Wenyun Liu, Donna L, et al.J. Cell Biol., Oct 2003; 163: 27.
2. Robert Spoelgen, Christine A. F. von Arnim, et al. J. Neurosci., Jan 2006; 26: 418 - 428.
2. Robert Spoelgen, Christine A. F. von Arnim, et al. J. Neurosci., Jan 2006; 26: 418 - 428.
Sequence
227-289
Diagram
| Immunohistochemistry |
Immunohistochemical analysis of paraffin-embedded human Alzheimer brain tissue, showing cytoplasmic localization using APP mouse mAb with DAB staining. |
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