RB
图片
- Immunohistochemistry
Immunohistochemical staining of paraffin-embedded human normal esophagus (A) and stomach (B) tissue, showing nucleus localization using Rb mouse mAb with DAB staining.
Mouse Antibody to RB
Catalog#
: 20032
| Size/Concentration： | 50ul | 100μl | |
| Price:￥ | 1280 | 2180 |
Instruction: 
Specification
| Entrez GeneID | 5925 |
| Aliases | RB; pRb; OSRC; pp110; p105-Rb; RB1 |
| Clone# | 7E4B8 |
| Host/Isotype | Mouse IgG1 |
| Storage | 4℃; -20℃ for long term storage. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human RB expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application
| ELISA | 1/10000 |
| IHC | 1/200 - 1/1000 |
Description
The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).
References
1. Oncogene 19: 562-570.
2. Cell 81: 323-330.
2. Cell 81: 323-330.
Sequence
774-927
Diagram
| Immunohistochemistry |
Immunohistochemical staining of paraffin-embedded human normal esophagus (A) and stomach (B) tissue, showing nucleus localization using Rb mouse mAb with DAB staining. |
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