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MCL-1

Western blot analysis using MCL1 mouse mAb against Hela (1), BCBL-1 (2), Jurkat (3) and HL60 (4) cell lysate.
  • Western blot analysis using MCL1 mouse mAb against Hela (1), BCBL-1 (2), Jurkat (3) and HL60 (4) cell lysate.
  • Confocal Immunofluorescence analysis of HepG2 cells using MCL1 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
  • Immunohistochemical analysis of paraffin-embedded human lymphnode tissues using MCL1 mouse mAb with DAB staining.

图片

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    Western Blot

    Western blot analysis using MCL1 mouse mAb against Hela (1), BCBL-1 (2), Jurkat (3) and HL60 (4) cell lysate.

  • fff
    Immunofluorescence

    Confocal Immunofluorescence analysis of HepG2 cells using MCL1 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

  • fff
    Immunohistochemistry

    Immunohistochemical analysis of paraffin-embedded human lymphnode tissues using MCL1 mouse mAb with DAB staining.

Mouse Antibody to MCL-1
Catalog#   :  20027
Size/Concentration： 50ul100μl
Price:￥ 12802180
Instruction:
Specification
Entrez GeneID4170
AliasesEAT, MCL1L, MCL1S
Clone#8C6D4B1
MW37kDa
Host/IsotypeMouse IgG1
Storage4℃; -20℃ for long term storage. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human MCL-1 expressed in E. Coli.
FormulationPurified antibody in PBS containing 0.03% sodium azide.
Application
ELISA1/10000
WB1/500 - 1/2000
ICC1/200 - 1/1000
IHC1/200 - 1/1000
Description
Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that
increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or
exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related
protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This
monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.
References
1. Ota, N. et al. J. Hum. Genet. 2000. 46: 254-269.
2. Schwertfeger KL, Ryder JW, Anderson SM J Mammary Gland Biol Neoplasia 2000, 3 : 236-251.

Diagram
Western Blot

Western blot analysis using MCL1 mouse mAb against Hela (1), BCBL-1 (2), Jurkat (3) and HL60 (4) cell lysate.

Immunofluorescence

Confocal Immunofluorescence analysis of HepG2 cells using MCL1 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

Immunohistochemistry

Immunohistochemical analysis of paraffin-embedded human lymphnode tissues using MCL1 mouse mAb with DAB staining.

 

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