Mouse Antibody to IL-10
Catalog#
: 20011
| Size/Concentration： | 50ul | 100μl | |
| Price:￥ | 1280 | 2180 |
Instruction: 
Specification
| Entrez GeneID | 3586 |
| Aliases | IL10 |
| Clone# | 3C12C12 |
| Host/Isotype | Mouse IgG1 |
| Storage | 4℃; -20℃ for long term storage. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IL-10 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application
| ELISA | 1/10000 |
Description
Interleukine 10 (IL-10) is a cytokine produced primarily by monocytes and to a lesser extent by
lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-
regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on
macrophages. It also enhances B cell survival, proliferation, and antibody production. This
cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling
pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-
regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on
macrophages. It also enhances B cell survival, proliferation, and antibody production. This
cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling
pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
References
1. Vieira P, et al. PNAS, 1991.88:1172-1176.
Diagram