Mouse Antibody to IFN-gamma
Catalog#
: 20009
| Size/Concentration： | 50ul | 100μl | |
| Price:￥ | 1280 | 2180 |
Instruction: 
Specification
| Entrez GeneID | 3458 |
| Aliases | IFG; IFI |
| Clone# | 3F1E3 |
| MW | 19.3kDa |
| Host/Isotype | Mouse IgG1 |
| Storage | 4℃; -20℃ for long term storage. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IFN-γ expressed in E. Coli. |
| Formulation | Purified antibody in PBS containing 0.03% sodium azide. |
Application
| ELISA | 1/10000 |
Description
Interferon-? (IFN-?) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-? strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB
References
1. Takayanagi, H. et al. Nature 2000. 408: 600-605.
2. Tsubota, K. et al. Invest. Ophthal. Vis. Sci. 40: 28-34, 1999.
2. Tsubota, K. et al. Invest. Ophthal. Vis. Sci. 40: 28-34, 1999.
Diagram