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ER-alpha

Western blot analysis using ER-alpha mouse mAb against human breast carcinoma tissue lysate.
  • Western blot analysis using ER-alpha mouse mAb against human breast carcinoma tissue lysate.
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using ER-alpha mouse mAb showing nuclear expression with DAB staining.

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    Western Blot

    Western blot analysis using ER-alpha mouse mAb against human breast carcinoma tissue lysate.

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    Immunohistochemistry

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using ER-alpha mouse mAb showing nuclear expression with DAB staining.

Mouse Antibody to ER-alpha
Catalog#   :  20047
Size/Concentration： 50ul100μl
Price:￥ 12802180
Instruction:
Specification
Entrez GeneID2099
AliasesER; ESR1; Era; ESRA
Clone#2B7
Host/IsotypeMouse IgG1
Storage4℃; -20℃ for long term storage. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ER-alpha (410-592aa) expressed in E. Coli.
FormulationPurified antibody in PBS containing 0.03% sodium azide.
Application
ELISA1/10000
WB1/500 - 1/2000
IHC1/200 - 1/1000
Description
The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells.
References
1. Paech K. Science 1997, 277: 1508- 10.
2. Pertschuk LP,Cancer, 1996. 199677: 514- 9.
Sequence

410-592


Diagram
Western Blot

Western blot analysis using ER-alpha mouse mAb against human breast carcinoma tissue lysate.

Immunohistochemistry

Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using ER-alpha mouse mAb showing nuclear expression with DAB staining.

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